VITVO can be loaded with human primary tumor cells dissociated after biopsies or surgery to grow them into their recreated 3D microenvironment and test them with different drugs for predictive purposes.

VITVO 3D细胞培养生物反应器

品牌：

Rigenerand

货号：

F000001

规格：

6 pcs/package

价格：

询价

数量：

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- 产品概况
  - A novel-generation 3D cell culture bioreactor for rapid cell colonization in a 3D manner enabling an in vitro real reconstruction of tissue complexity, in an in vivo-like microenvironment.
    VITVO it’s a ready to use, flat and handheld bioreactor, integrating scaffold for the establishment of in vitro 3D cell culture model that can be used for a large number of research applications and pre-clinical investigations. This in vitro 3D cell culture technology offers also a solution for precision medicine approaches.
    
    HOW TO WORK
    VITVO 3D Bioreactor’s matrix inner core is a fiber-based 3D scaffold optimized for cell retainment, engraftment, and colonization. Cells colonize within the 3D matrix by adhering to the fibers , or forming aggregates within 90% of its empty volume. Our cell culture bioreactor can host human and animal cells – making it a concrete solution for reducing and replacing small animal studies with both ethical and economic impacts in drug development.
    
    ADVANTAGES
    -Three dimensional (3D) platforms have potential to provide more physiologic environments for cell culture in drug discovery and toxicology than classical 2D culture systems.
    -3D culture allows a greater predictivity of efficacy and toxicity before putative drugs move into pre-clinical animal testing and towards clinics, lowering the attrition rate of drug development.
    -3D cultures retain the advantage to mimic an in vivo-like context enabling drug safety and efficacy testing in a human avatar environment.
    -3D culture leads to a different modulation of gene expression, ultimately influencing the antigenic profile of the cells and closely mimicking an in vivo environment.
- 产品特性
  - 保存
    
    Two years shelf life
    
    外观
    
    Matrix volume: 4 cm2 (area) x 400 µm (thickness)
    Empty volume: 90% of matrix volume
    
    类别
    
    3D bioreactor
    
    其他性质
    
    Biological safety: Inert, biocompatible and xeno-free; DNAse/RNAse free
    Sterilization: Electron-beam processing
    
    *本产品仅限于专业人员的科学研究使用，不得用于食品、临床诊断或治疗。
- 产品应用
  - 应用说明
    
    • To address chemotherapy/TKI efficacy in 3D To minimize animal uses (3R)
    • To address cell therapies efficacy (possibility to load Targets and Effectors at variable ratios in a 3D relevant model CAR-T, MSC)
    • To address biologics efficacy in 3D (PD/PK), i.e tumor penetration of a monoclonal antibody
    • To address putative drug toxicity in 3D (hepatocytes)
    • To host tumor spheroids (Glioblastoma) also loaded in the two faces
    • Cancer metabolomics (i.e. tumor/stroma interaction)
    • Histology testing after cell loading (methacrylate embedding)
    • Histology testing after cytotoxicity (surrogate of minimal residual disease)
    • Migration assays in 3D
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