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产品概况
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A novel-generation 3D cell culture bioreactor for rapid cell colonization in a 3D manner enabling an in vitro real reconstruction of tissue complexity, in an in vivo-like microenvironment.
VITVO it’s a ready to use, flat and handheld bioreactor, integrating scaffold for the establishment of in vitro 3D cell culture model that can be used for a large number of research applications and pre-clinical investigations. This in vitro 3D cell culture technology offers also a solution for precision medicine approaches.
HOW TO WORK
VITVO 3D Bioreactor’s matrix inner core is a fiber-based 3D scaffold optimized for cell retainment, engraftment, and colonization. Cells colonize within the 3D matrix by adhering to the fibers , or forming aggregates within 90% of its empty volume. Our cell culture bioreactor can host human and animal cells – making it a concrete solution for reducing and replacing small animal studies with both ethical and economic impacts in drug development.
ADVANTAGES
-Three dimensional (3D) platforms have potential to provide more physiologic environments for cell culture in drug discovery and toxicology than classical 2D culture systems.
-3D culture allows a greater predictivity of efficacy and toxicity before putative drugs move into pre-clinical animal testing and towards clinics, lowering the attrition rate of drug development.
-3D cultures retain the advantage to mimic an in vivo-like context enabling drug safety and efficacy testing in a human avatar environment.
-3D culture leads to a different modulation of gene expression, ultimately influencing the antigenic profile of the cells and closely mimicking an in vivo environment.
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A novel-generation 3D cell culture bioreactor for rapid cell colonization in a 3D manner enabling an in vitro real reconstruction of tissue complexity, in an in vivo-like microenvironment.
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产品特性
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保存Two years shelf life外观Matrix volume: 4 cm2 (area) x 400 µm (thickness)
Empty volume: 90% of matrix volume类别3D bioreactor其他性质Biological safety: Inert, biocompatible and xeno-free; DNAse/RNAse free
Sterilization: Electron-beam processing*本产品仅限于专业人员的科学研究使用，不得用于食品、临床诊断或治疗。
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产品应用
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应用说明• To address chemotherapy/TKI efficacy in 3D To minimize animal uses (3R)
• To address cell therapies efficacy (possibility to load Targets and Effectors at variable ratios in a 3D relevant model CAR-T, MSC)
• To address biologics efficacy in 3D (PD/PK), i.e tumor penetration of a monoclonal antibody
• To address putative drug toxicity in 3D (hepatocytes)
• To host tumor spheroids (Glioblastoma) also loaded in the two faces
• Cancer metabolomics (i.e. tumor/stroma interaction)
• Histology testing after cell loading (methacrylate embedding)
• Histology testing after cytotoxicity (surrogate of minimal residual disease)
• Migration assays in 3D
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产品概况
